Last update
3/14/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 59 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
Read More
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
Read More
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
Read More
Most Useful Reviews
9
Great overall health
4 people found this helpful
After two months of selenium, I feel fantastic. My skin glows, my mood has improved, and my fatigue has dissipated. I believe this is one of the best products for overall health maintenance, and the tablets are easy to swallow.
Read More
7.5
Thyroid support
4 people found this helpful
This product effectively alleviates my fatigue since it aids in iodine absorption, ensuring my thyroid gland functions optimally. I recommend taking it before lunch.
Read More
10
Feeling cheerful
Excellent! After using this supplement, chronic fatigue syndrome dissipated, and I've felt much more cheerful. I take it for my thyroid health, especially since I live in an industrial area.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
Read More
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
Read More
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 59 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Great overall health
4 people found this helpful
After two months of selenium, I feel fantastic. My skin glows, my mood has improved, and my fatigue has dissipated. I believe this is one of the best products for overall health maintenance, and the tablets are easy to swallow.
Read More
7.5
Thyroid support
4 people found this helpful
This product effectively alleviates my fatigue since it aids in iodine absorption, ensuring my thyroid gland functions optimally. I recommend taking it before lunch.
Read More
10
Feeling cheerful
Excellent! After using this supplement, chronic fatigue syndrome dissipated, and I've felt much more cheerful. I take it for my thyroid health, especially since I live in an industrial area.
Read More
10
Much more cheerful
Excellent! After taking the drug, Chronic Fatigue Syndrome vanished. I began to feel significantly more cheerful. I take it for my thyroid health, as I live in an industrial city.
Read More
10
Increased energy levels
What a find! Life has become easier; I felt awful, merely existing. Muscle pain, severe weakness, and hair falling out in clumps were my reality. After discovering a selenium deficiency, I began taking two selenium tablets from this company, and I can genuinely say I started to live again. I now have energy, barely any hair loss, and I don't feel an immediate need to sleep after eating; my chronic fatigue has vanished. However, it's essential to consult a doctor regarding dosage and deficiency before starting. Selenium has a cumulative effect and must be taken carefully to avoid harm. Stay healthy!
Read More
Frequently Asked Questions
7.5
Significant energy boost
98 people found this helpful
I've been using the product for two weeks, and I've noticed a significant improvement in my energy levels. I would recommend this to anyone suffering from fatigue or general exhaustion. Life is long enough, and stress can be debilitating, affecting both physical and mental health.
9
Great overall health
4 people found this helpful
After two months of selenium, I feel fantastic. My skin glows, my mood has improved, and my fatigue has dissipated. I believe this is one of the best products for overall health maintenance, and the tablets are easy to swallow.
9
Fatigue reduction
I’ve noticed that the fatigue disappears after taking this supplement.
7.5
Improved energy levels
1 people found this helpful
Since taking the supplement, my energy levels and mental clarity have significantly improved. I feel alert and focused throughout the day, accomplishing more without the weariness. It's easy to take and has not caused any negative side effects.
9
Improved energy
1 people found this helpful
Since starting this supplement, my overall well-being has improved swiftly. The fatigue has decreased remarkably, especially when combined with L-tyrosine. Drowsiness and weakness have subsided, leaving me with energy and clarity. I truly appreciate this combination.
6
Reliable supplement
2 people found this helpful
I consistently purchase from this trustworthy brand, which offers excellent hermetic packaging and a convenient cap. I bought selenium for hair shedding, and it has numerous benefits. It has helped my immune system and reduced my fatigue, making it easier to combine with biotin.
9
Long-term use
This is the best antioxidant for me; I intend to take it for life. Taking one pill twice daily has made a noticeable difference. My fatigue has been considerably reduced.
7.5
Eye relief
1 people found this helpful
This supplement is fantastic for my thyroid eye disease. It has alleviated symptoms like fatigue and watering in my eyes. I’ve noticed improvement since taking these daily; missing doses makes symptoms return, indicating a possible selenium deficiency.
9
Fatigue relief
1 people found this helpful
Selenium has significantly helped me; my fatigue has vanished and my whole body feels rejuvenated. It turns out I was deficient in this vitamin. Thank you!
8
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
7
CoQ10 and selenium may benefit ME/CFS
We explored whether combining Coenzyme Q10 and selenium could improve outcomes for individuals with chronic fatigue syndrome (ME/CFS). In this study, 27 patients took an oral supplement for 8 weeks. While we noted improvements in overall fatigue severity and quality of life, sleep disturbances did not show any significant change. Additionally, we found increased antioxidant capacity and decreased inflammatory markers, indicating potential benefits. However, other key biomarkers did not show significant changes. Overall, this suggests that long-term supplementation might help some symptoms in ME/CFS.
8
We explored how sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) might help alleviate symptoms of chronic fatigue syndrome (CFS). In this study, we used mouse models to test the effects of these nanoparticles, which were created using an ultrasound-assisted method.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
While the U-SCPSeNPs showed promise in improving energy production and enhancing gut microbiota, the results indicated no significant improvement in clinical symptoms of CFS. Thus, while interesting, the potential of selenium treatment for CFS remains unproven.
References
- Wang J, Wang X, Xiu W, Li C, Yu S, et al. Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome. Food Funct. 2025;16:133. 10.1039/d4fo04195j
- Castro-Marrero J, Domingo JC, Cordobilla B, Ferrer R, Giralt M, et al. Does Coenzyme Q10 Plus Selenium Supplementation Ameliorate Clinical Outcomes by Modulating Oxidative Stress and Inflammation in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?. Antioxid Redox Signal. 2022;36:729. 10.1089/ars.2022.0018
- Shao C, Song J, Zhao S, Jiang H, Wang B, et al. Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome. Polymers (Basel). 2018;10. 10.3390/polym10111269
Data last updated:
